Several species of the parasite Plasmodium cause human malarial diseases, and, despite determined control efforts, a huge global disease burden remains. Howick et al. present a single-cell analysis of…

A ten-year collaboration gives biotech giant Gilead first rights to all of Galapagos’s pipeline.

Autologous iPSC-derived cell products are not inherently non-immunogenic - and the mitochondria might be to blame

Recent actions by government agencies and universities with respect to Chinese scientists in the U.S. could threaten U.S. leadership in biomedical science

A new study UC San Francisco has shown that mutations in mitochondrial DNA induced by cell reprogramming may trigger an immune response.

Targeting two antigens with BiTE-secreting CAR-T cells limits tumor immune escape in glioblastoma.

The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and…

A DNA-based amplification scheme enables highly multiplexed immunofluorescence imaging

The authors designed stapled antimicrobial peptides that have potent antibacterial activity in mice and limited toxicity.

Mitochondrial DNA mutations in iPSCs can render them immunogenic.

A simple and robust DNA-based signal amplification method to simultaneously visualize multiple proteins in tissues has the potential to accelerate many large-scale protein mapping and biomarker…

Study shows that the adult-to-iPSC conversion process can mutate DNA found in mitochondria, causing mice and humans to reject iPSCs, and stem cell transplants more generally.

The authors tested the ability of hESC-derived epicardium to augment the structure and function of engineered heart tissue in vitro and to improve efficacy of hESC-cardiomyocyte grafts in infarcted…

Kary Mullis was an unconventional and often controversial Nobel laureate.

A team of researchers from institutions in the U.S., Germany and China has developed a way to improve the accuracy of long-read genome sequencing. In their paper published in the journal Nature…

Venture investors and even some other biopharma giants appear much more optimistic about gene editing-based companies, given the year-over-year increases in total capital raised by many such startups, including those highlighted on this A-List.

Non-invasive stimulation of the brain is being touted to promote health and well-being and for ‘curing’ disease, but the mechanistic underpinnings of the devices remain unclear.

Cutting-edge DNA technologies have discovered thousands of bugs in cows’ stomachs that could improve meat and dairy production, and keep cattle healthy.

Anikeeva and colleagues review the state of the art in technologies that enable discoveries of brain function and the development of novel therapeutic approaches.

PacBio strives to remove the choice between length and accuracy by optimizing their circular consensus sequencing method.

Despite dazzling lab demonstrations, robust and viable clinical interventions using brain–computer interfaces remain some way off.

The protection of intellectual property is vital to innovation. If anyone can just take something you created -- be it a song or a drug -- without proper compensation, there would be little reason to…

High-fidelity reads improve variant detection and genome assembly on the PacBio platform.